Paclitaxel ptx, one of the most effective chemotherapeutic agents, presents great potency in treatment of a broad spectrum of solid tumors, such as breast cancer, refractory ovarian cancer and nonsmall cell lung carcinoma goldspiel, 1997, howat et al. Development of egfr targeted nanoemulsion for imaging and. Coadministration of paclitaxel and curcumin in nanoemulsion. Mar 11, 2009 paclitaxel and curcumin coadministration in novel cationic pegylated niosomal formulations exhibit enhanced synergistic antitumor efficacy.
Sensitization of taxolinduced apoptosis by curcumin. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. However, multidrug resistance is usually developed in clinical trials using. However, multidrug resistance is usually developed in clinical trials using ptx alone or. Exceedingly higher coloading of curcumin and paclitaxel.
Vitamin erich nanoemulsion has great potential for the treatment of breast cancers with a low dose of paclitaxel via driving th1 immune response. Pdf coadministration of paclitaxel and curcumin in. Furthermore, nanoemulsion neloaded ptx and bez235 were more effective than the free drug, and a combination treatment of both ne drugs increased the efficiency of the treatments. Nanoemulsions as versatile formulations for paclitaxel. The combination caused significantly enhanced antitumor activity in.
However, the release kinetics in phosphate buffer saline was 1. Gbm is a very aggressive disease and the average patient lifespan is reduced to 6 months after diagnosis. Aug 22, 20 ganta s, amiji m 2009 coadministration of paclitaxel and curcumin in nanoemulsion formulations to overcome multidrug resistance in tumor cells. Paclitaxel and curcumin coadministration in novel cationic pegylated niosomal formulations exhibit enhanced synergistic antitumor efficacy. In this study, our main objective was to evaluate co administration of paclitaxel ptx and curcumin cur, a modulator of mrp and an inhibitor of nuclear factor kappa b nf and b signaling, in oilinwater nanoemulsion formulations in brain tumor cells. Cytotoxicity and apoptosis enhancement in brain tumor. A, hela cells were treated with taxol 5 n m andor curcumin 5. Coadministration of paclitaxel and curcumin in nanoemulsion formulations to overcome multidrug resistance in tumor cells. Sensitization of taxolinduced apoptosis by curcumin involves. Nanoemulsions are colloidal dispersion systems that are thermodynamically stable, composed of two immiscible liquids mixed along with emulsifying agents surfactants and cosurfactants to form a single phase. Pathogenesis of psoriasis involves the keratinocytes in epidermis as well as the angiogenesis involving deeper skin layers. Pdf paclitaxel and curcumin coadministration in novel. The chemical structures of paclitaxel and curcumin.
Preclinical studies for the combination of paclitaxel and curcumin in. When paclitaxel and curcumin were combined the expression of bcl2 protein was decreased. Mar 08, 2017 the aim of this study is to assess benefits of treatment with intravenous curcumin cuc01 vs placebo, in combination with paclitaxel chemotherapy, and to estimate the risk of adverse events in patients with locally advanced and metastatic breast cancer. Shapecontrolled paclitaxel nanoparticles with multiple. Targeted coadministration of sparingly soluble paclitaxel and curcumin into cancer cells by. Exceedingly higher coloading of curcumin and paclitaxel onto. Curcumin enhances oral bioavailability and antitumor therapeutic. Curcumin in combination with chemotherapy in advanced. Abstract the aim of this study was to evaluate the effect of curcumin cur.
Coadministration of paclitaxel and curcumin in nanoemulsion formulations to overcome multidrug resistance in tumor cells mol. Coadministration of paclitaxel and curcumin in nanoemulsion formulations to overcome multidrug resistance in tumor cells article in molecular pharmaceutics 63. A differential interference contrast image of the u118 cells, b rhodaminelabeled paclitaxel ptx nanoemulsion uptake imaged with red emission filter, c nbdlabeled c 6ceramide cer nanoemulsion uptake imaged with green emission filter, and d an overlay of b and c images showing colocalization of ptx and cer in the cells with the. Simultaneous delivery of doxorubicin and curcumin encapsulated in liposomes of pegylated rgdklipopeptide to tumor. The aim of this study was to evaluate the effect of curcumin cur in oral bioavailability and therapeutic efficacy of paclitaxel ptx administered in nanoemulsion to skov3 tumorbearing nunu mice. Zhan et al showed that combination of paclitaxel and curcumin. Combination of curcumin and paclitaxelloaded solid lipid. Oral administration of the mice with cur at 50 mgkg for 3 consecutive days resulted in a down regulation of intestinal p. Efficiency against multidrug resistance by codelivery of. Review of nanoemulsion formulation and characterization. Oral administration of the mice with cur at 50 mgkg for 3 consecutive days resulted in a down regulation of intestinal pglycoprotein pgp and.
Excipient selection and aerodynamic characterization of. Immunocytometric analysis of mrp expression in u87 and t98g glioblastoma cells. Incorporation of paclitaxel into lipid nanoparticles partially recovered the anticancer activity of paclitaxel in mcf7adr. Evaluation of the efficacy of paclitaxel with curcumin. The objective of this study was to examine augmentation of therapeutic activity in human glioblastoma cells with combination of paclitaxel ptx and the apoptotic signaling molecule, c 6ceramide cer, when administered in novel oilinwater nanoemulsions. We are excited about the results of the study and the possible implications for taking the findings into the clinic in the next several years, says bharat aggarwal, ph. Plgaphospholipidpeg nanoparticles were prepared using the nano precipitation method. Pdf curcumin enhances oral bioavailability and anti. Recent advances in nanoformulations for codelivery of. Ganta s, amiji m 2009 coadministration of paclitaxel and curcumin in nanoemulsion formulations to overcome multidrug resistance in tumor cells. Mar 21, 2017 furthermore, vitamin erich nanoemulsion exhibited superior in vivo antitumor efficacy in comparison with taxol and vitamin elow nanoemulsion at a paclitaxel dose of 4 mgkg. Proposed multimodal mechanism of mdr modulation with curcumin.
A mixture of two immiscible substances in which the sizes of the particles in the dispersed phase are defined as less than nanometers. Multifunctional nanoemulsion system for combination paclitaxel and. Molecular evidences for the chemosensitizing efficacy of. Jun, 2019 the drug release study was performed by centrifugation method wallace et al. Preparation of lipid nanoemulsions incorporating curcumin for. Pdf targeted coadministration of sparingly soluble paclitaxel and. Solidnanoemulsion preconcentrate for oral delivery of. The aim of the present study was to evaluate the efficacy of paclitaxel combined with curcumin cur against drug resistance in ovarian cancer cells. Curcumin breaks down the dose, making the therapy less toxic and just as powerful while delivering the same level of efficacy. At specific time intervals, sample was centrifuged at 30000 rpm for 30 min and the supernatant was analyzed for drug content using uvvis spectrophotometer at 200 nm and 421 nm for paclitaxel and curcumin, respectively. Wed like to understand how you use our websites in order to improve them. Some of the clinical challenges in gbm include difficulty in initial diagnosis, presence of tumor cell islets in the critical areas of the.
To increase chemotherapeutic efficacy while reducing toxic effects, a rational design for. It is used in cancer treatment due to its ability to arrest the division of cell during mitosis by preventing disassembly of the microtubule, which results in cell death. Cytotoxicity and apoptosis enhancement in brain tumor cells. In the present study, the solid nanoemulsion preconcentrate of paclitaxel has shown good thermodynamic stability with prompt emulsification and optimum drug release in the biological fluid. Heres that very promising study regarding taking turmeric. Pdf on jan 1, 2018, tushar hemant nikam and others published nanoemulsion. Comparable claims are made by somasundaram and lopezlazaro burgosmoron among others of curcumins interference with the proapoptotic activities of other chemotherapies such as paclitaxel taxol, although we have divergent reports such as those of srinivas ganta and colleagues 70,71 at northeastern university of curcumininduced. How turmeric protects from chemotherapy induced toxicity. Curcumin enhances oral bioavailability and antitumor. Multifunctional nanoemulsion system for combination. Full text synergistic inhibition of colon cancer cell. Singh department of pharmaceutical sciences, guru jambheshwar university of science and technology, hisar, haryana125 001, india gurpreet, et al formulation and characterization of nanoemulsion. Coadministration of curcumin and paclitaxel nanoemulsion formulations are capable of conquering multidrug resistance in skov3 tr human ovarian. Request pdf curcumin enhances oral bioavailability and antitumor therapeutic efficacy of paclitaxel upon administration in nanoemulsion formulation the.
Oral administration of the mice with cur at 50 mgkg for 3 consecutive days resulted in a down regulation of intestinal pglycoprotein pgp and cytochrome p450 3a2 cyp3a2 protein levels. Transmission electron micrograph of pinenut oil nanoemulsion for the co administration of paclitaxel and curcumin. Evidencebased breast cancer treatment and prevention. Folatemodified, curcumin and paclitaxel coloaded platpgs.
Vitamin erich nanoemulsion enhances the antitumor efficacy. Curcumin alone and combined with paclitaxel increased p53, bid, caspase3, caspase8 and bax gene expression in mdamb231, whereas bclxl decreased such expression in mdamb231 cells. Current applications of nanoemulsions in cancer therapeutics mdpi. Mdr can be intrinsic innate or acquired through exposure to chemotherapeutic agents. Development of egfrtargeted nanoemulsion for imaging. In this investigation, in order to achieve penetration of pcl into deeper skin layers while minimizing the systemic escape, a nanoemulsion ne was formulated and. If refractive index of nanoemulsion has equal refractive index as that of water, then the nanoemulsion is considered to have transparent nature 2. So, the drug delivery strategy should be customized to localize paclitaxel pcl inside both layers. The combination could improve oral bioavailability and therapeutic efficacy in. But and heres the good newstalking about curcumin an ingredient in easily obtainable turmeric.
Egfr targeted theranostic nanoemulsion for imageguided. A tpgsincorporating nanoemulsion of paclitaxel circumvents drug resistance in breast cancer. However, curcumin inhibited pgpmediated efflux of calcein in a dosedependent manner even though it showed lower activity compared to verapamil, a wellknown pgp inhibitor. In this study, we demonstrated that paclitaxel ptx together with bez235 exhibited a synergetic inhibition effect on colon cancer cell growth. Folatemodified, curcumin and paclitaxel coloaded platpgs nanoparticles. Amijicoadministration of paclitaxel and curcumin in nanoemulsion formulations to overcome multidrug resistance in tumor cells mol pharm, 6 2009, pp. The development of multidrug resistant mdr cancer is a barrier to the successful treatment of many clinical cases of cancer. Biodistribution and pharmacokinetic analysis of paclitaxel. The nanoemulsions were formulated with pinenut oil, which has high concentrations of essential polyunsaturated fatty acid pufa. The systemic administration of cytotoxic chemotherapeutic agents for cancer treatment often has toxic side effects, limiting the usage dose. Nanoemulsions have extensively been investigated as drug delivery systems. Milkderived exosomes for oral delivery of paclitaxel.
Administration of paclitaxel and curcumin combination in nanoemulsion formulations elevated the cytotoxicity in wildtype skov3 and drugresistant skov3 tr human ovarian cancer cells by modulating their apoptotic response. Effect of curcumin and paclitaxel on breast carcinogenesis. Formulation and evaluation of paclitaxel loaded nanoemulsion for pulmonary administration by ahmed s. Sensitization of taxolinduced apoptosis by curcumin is independent of tubulin polymerization and cell cycle arrest. Review of nanoemulsion formulation and characterization techniques k. Issn 03785173 it is advisable to refer to the publishers version if you intend to cite from the work. A new safe and effective formulation to prevent tumor reincidence and metastasis article in nanoscale 10suppl 1 december 2018 with 175 reads how we measure reads. Novel paclitaxel formulations solubilized by parenteral. Coadministration of paclitaxel and curcumin in nanoemulsion formulations to. Curcumin alone and combined with paclitaxel increased p53, bid, caspase3, caspase8 and bax gene expression in mdamb231, whereas decreased bclxl such expression in mdamb231 cells. Paclitaxel and curcumin coadministration in novel cationic. Solid nanoemulsion preconcentrate system seems to be a good approach to increase the bioavailability for hydrophobic drugs such as paclitaxel. Utilization of curcumine and nanocurcumine compounds in cancer. Synergistic inhibition of colon cancer cell growth with.958 191 456 1389 1623 924 1596 1043 108 494 480 467 555 450 1026 1096 509 609 1489 642 317 851 1381 458 1533 689 923 282 361 714 1125 987 937 145 935 524 115 466 1010 1033 751 884 479